Academic Funding

The Perils of Industry Funded Research

November 4, 2019 2173
A man putting money in his coat pocket (suspiciously)

Over the last two decades, industry funding for medical research has increased globally, while government and non-profit funding has decreased. By 2011, industry funding, compared to public sources, accounted for two-thirds of medical research worldwide.

Research funding from other industries is increasing too, including food and beverage, chemical, mining, computer and automobile companies. And as a result, academic freedom suffers.

Industry sponsors suppress publication

An early career academic recently sought my advice about her industry-funded research. Under the funding contract – that was signed by her supervisor – she wouldn’t be able to publish the results of her clinical trial.

Another researcher, a doctoral student, asked for help with her dissertation. Her work falls under the scope of her PhD supervisor’s research funding agreement with a company. This agreement prevented the publication of any work deemed commercial-in-confidence by the industry funder. So, she will not be allowed to submit the papers to fulfill her dissertation requirements.

I come across such stories often and they all have one thing in common. The blocked publications present the sponsoring companies’ products in an unfavorable way. While the right to publish is a mainstay of academic freedom, research contracts often include clauses that give the funder the final say on whether the research can be published.

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This article by Lisa Bero originally appeared at The Conversation, a Social Science Space partner site, under the title “When big companies fund academic research, the truth often comes last

Early career researchers are particularly vulnerable to publication restrictions when companies fund their research. Scientific publication is vital to their career advancement, but their supervisors may control the research group’s relationship with industry.

Senior researchers can also be vulnerable to industry suppressing their research. In the 1980s, a pharmaceutical company funded a researcher to compare their brand’s thyroid drug to its generic counterparts. The researcher found the generics were as good as the branded products.

The funder then went to great lengths to suppress the publication of her findings, including taking legal action against her and her university.

And there is little institutional oversight. A 2018 study found that, among 127 academic institutions in the United States, only one-third required their faculty to submit research consulting agreements for review by the institution.

And 35 percent of academic institutions did not think it was necessary for the institution to review such agreements. When consulting agreements were reviewed, only 23 percent of academic institutions looked at publication rights. And only 19 percent looked for inappropriate confidentiality provisions, such as prohibiting communication about any aspect of the funded work.

Industry sponsors manipulate evidence

The definition of academic freedom boils down to freedom of inquiry, investigation, research, expression and publication (or dissemination).

Internal industry documents obtained through litigation have revealed many examples of industry sponsors influencing the design and conduct of research, as well as the partial publication of research where only findings favorable to the funder were published.

For instance, in 1981 an influential Japanese study showed an association between passive smoking and lung cancer. It concluded wives of heavy smokers had up to twice the risk of developing lung cancer as wives of non-smokers and that the risk was dose related.

Tobacco companies then funded academic researchers to create a study that would refute these findings. The tobacco companies were involved in every step of the funded work, but kept the extent of their involvement hidden for decades. They framed the research questions, designed the study, collected and provided data, and wrote the final publication.

This publication was used as “evidence” that tobacco smoke is not harmful. It concluded there was no direct evidence passive smoke exposure increased risk of lung cancer. The tobacco industry cited the study in government and regulatory documents to refute the independent data on the harms of passive smoking.

Industry sponsors influence research agendas

The biggest threat to academic freedom may be the influence industry funders have on the very first stage in the research process: establishing research agendas. This means industry sponsors get unprecedented control over the research questions that get studied.

We recently reviewed research studies that looked at corporate influence on the research agenda. We found industry funding drives researchers to study questions that aim to maximize benefits and minimize harms of their products, distract from independent research that is unfavorable, decrease regulation of their products, and support their legal and policy positions.

In another tobacco-related example, three tobacco companies created and funded The Center for Indoor Air Research that would conduct research to “distract” from evidence for the harms of second-hand smoke. Throughout the 1990s, this center funded dozens of research projects that suggested components of indoor air, such as carpet off-gases or dirty air filters, were more harmful than tobacco.

The sugar industry also attempted to shift the focus away from evidence showing an association between sugar and heart disease. It was only recently revealed that, in the 1960s, the sugar industry paid scientists at Harvard University to minimize the link between sugar and heart disease, and to shift the blame from sugar to fat as being responsible for the heart disease epidemic/

The paper’s authors suggested many of today’s dietary recommendations may have been largely shaped by the sugar industry. And some experts have since questioned whether such misinformation can have led to today’s obesity crisis.

Coca-Cola and Mars have also funded university research on physical activity to divert attention away from the association of their products with obesity.

How do we protect academic freedom?

In a climate where relations between academia and industry are encouraged and industry funding for research continues to grow, academics must guard against threats to academic freedom posed by industry support.

Academic freedom means industry funding must come with no strings attached. Researchers must ask themselves if accepting industry funding contributes to the mission of discovering new knowledge or to an industry research agenda aimed at increasing profits.

Governments or independent consortia of multiple funders, including government and industry, must ensure support for research that meets the needs of the public.

When research is supported by industry, funders should not dictate the design, conduct or publication of the research. Many universities have and enforce policies that prevent such restrictions, but this is not universal. Open science, including publication of protocols and data, can expose industry interference in research.

Scientists should never sign, or let their institution sign, an agreement that gives a funder power to prevent dissemination of their research findings. Universities and scientific journals must protect emerging researchers and support all academics in fending off industry influence and preserving academic freedom.

Professor Lisa Bero is a pharmacologist and researcher in evidence-based health care who is internationally renowned for her studies on the integrity of clinical and basic research evidence that is used to influence health policy, and the manner in which evidence is communicated to key groups such as physicians, policy-makers, journalists and the community. Prior to joining the University of Sydney in 2014, she was Professor at the Department of Clinical Pharmacy and Institute for Health Policy Studies, University of California San Francisco (UCSF).

View all posts by Lisa Bero

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